A blistered foot, aching muscles and a growing rival in Novak Djokovic might slow down Rafel Nadal at Roland Garros.
Zverev won in four sets at Roland-Garros to send Alcaraz packing and reach the French Open semi-finals for a second straight year.
The season-ending championship title eluded Mahesh Bhupathi yet again as the Indian Davis Cupper and his partner Max Mirnyi lost the summit clash of the World Tour Finals to Daniel Nestor and Nenad Zimonjic in London on Sunday.
Rohan Bopanna and his doubles partner Florin Mergea qualified for the year-end ATP World Tour Finale when Vasek Pospisil and Jack Sock lost the Paris Masters final, on Sunday.
Medvedev moved a step closer to a potential semi-final showdown with Novak Djokovic at the Australian Open warm-up event.
Sparks flew when they met for the first time on the ATP Tour in Miami, with Medvedev confronting the Greek over his on-court conduct.
Frenchman Fabrice Santoro, once nicknamed "the magician" by Pete Sampras for his habit of mystifying bigger, stronger opponents, could perform one final, record-breaking trick before his remarkable career ends.
Summary of sports events and persons who made news on Wednesday
Novak Djokovic celebrated his return to the summit of world tennis with a stroll into the quarter-finals at the Paris Masters as outclassed Damir Dzumhur had to retire with injury in the second set of their third round clash.
Roger Federer has backed calls to shorten the tennis calendar to protect players from burnout by creating a six week off-season.
Tim Henman capped the finest week of his tennis career by winning the Paris Masters title with a straight sets defeat of Andrei Pavel.
The Australian wasted five match points and a chance to play in the season-ending Masters Cup when he was beaten 6-7, 7-6, 7-6 by Gustavo Kuerten.
The world number four said that he has yet to fully recover from a ligament tear in his left knee.
World number two Rafael Nadal said on Tuesday tennis is free of doping and repeated his view that the testing procedures are too tough. Nadal, who had previously accused controllers of "harassing" the players, said he has a problem with players having to inform anti-doping authorities of their whereabouts on a daily basis.
Andy Murray's winning streak came to an end when the world number three slumped to a 4-6, 7-6, 6-4 quarter-final defeat at the Paris Masters after a three-hour tussle against the fifth-seeded Czech Tomas Berdych on Friday.
Novak Djokovic ran into a spot of bother before seeing off Davis Cup team mate Viktor Troicki 4-6, 6-3, 6-1 to secure his place in the quarter-finals of the Paris Masters on Thursday. Czech Tomas Berdych booked his place for the ATP World Tour Finals with a 7-5, 6-4 win over Serb Janko Tipsarevic.
'Whilst I feel fit and healthy, I would like to give it a go.'
They were beaten by the Czech duo of Martin Damm and Cyril Suk in the first round of the Paris Masters.
Marat Safin, widely regarded as one of the most gifted players of his generation, brought down the curtain on a chequered career when he bowed out to US Open champion Juan Martin del Potro in the Paris Masters.
The Serb was knocked off top spot by Rafael Nadal on Monday despite winning the Paris Masters last week and will need a strong finish alongside the River Thames to snatch it back.
Sindhu, Sen look to regain lost touch in Canada Open
The 14-time Grand Slam winner said he is happy and proud to have reached the summit of the game for a fourth separate spell.
Home favourite Roger Federer barely broke sweat as he beat David Goffin 6-2, 6-2 to win the Basel Indoor title for the sixth time on Sunday.
The 22-year-old, 6ft 6in Russian, already the owner of two indoor hard court titles this year, moved one step away from the biggest title of his career at the Bercy indoor arena, crushing his Austrian friend in 70 one-sided minutes.
Frenchman Fabrice Santoro crushed Novak Djokovic 6-3, 6-2 in the second round of the Paris Masters.
Roger Federer's hopes of knocking Novak Djokovic off the top of the ATP world rankings before the end of the year took a hit when he lost to big-serving Canadian Milos Raonic in the Paris Masters quarter-finals on Friday.
Thailand's Paradorn Srichaphan says he will be fit to defend his Asian Games singles title in Doha next month.
Briton Andy Murray will take over from Novak Djokovic as World No 1 when the rankings are updated on Monday after his Paris Masters semi-final opponent Milos Raonic withdrew with a leg injury on Saturday.
With the ATP Finals coming up next month, Nadal said on his Facebook page he had made the decision to pull out of next week's Basel tournament after getting medical advice.
Andy Murray continued his remarkable run on clay.
With 1,500 points available for an undefeated champion next week, the tournament could produce a thrilling climax with Murray and Djokovic, who have never met at the O2, facing off in the final for the year-end number one ranking.
Holger Rune crashed out to Yoshihito Nishioka in the ATP 250 Adelaide International 1 first round.
Take a look at the five top contenders for the men's singles title at the French Open:
The towering Croatian, who has won 20 of his last 22 matches, will meet the unfancied Tomas Berdych in the Paris Masters final.
The world number three will meet Slovakian 16th seed Dominik Hrbaty in the third round of the Paris Masters.
"It happened to me but I will not tell you where or how," Arnaud Clement told reporters after his first-round defeat by Russia's Mikhail Youzhny at the Paris Masters Series tournament.
The two tennis aces are raring to go for next week's Masters Cup, which pits the best eight players in the world against each other.
The unseeded Henman beat Wimbledon champion Roger Federer while Roddick beat Jonas Bjorkman in the Paris Masters.